Peptide-nanotube composit material

Development of a novel composite material with carbon nanotubes assisted by self-assembled peptides designed in conjunction with β-sheet formation

Y. Hashida1, T. Umeyama, J. Mihara, H. Imahori, M. Tsujimoto1, S. Isoda1, M. Takano1, M. Hashida1,
J Pharm Sci , 2012, 101, 3398–3412 DOI: 10.1002/jps.23144

A novel composite material is developed with single-walled carbon nanotubes (SWCNTs) and artificially designed peptides, and its chemical and physicochemical characteristics are evaluated with an aim toward biomedical application. The peptides were designed to form a β-sheet structure that would be suitable for wrapping SWCNTs. The complex of SWCNTs and peptide (SWCNT–peptide) showed good dispersibility in aqueous media and was considerably stable even in the absence of an excess amount of peptide in the media. The formation of SWCNT–peptide was confirmed by its performance in water, atomic force microscopy and transmission electron microscopy observation, and molecular modeling. The possibility of introducing various functions to SWCNT–peptide was also demonstrated by several methods, such as introduction of special amino acids, chemical modification, and additional complex formation based on electrostatic interaction. These results suggest the potential of the SWCNT–peptide complex as a molecular platform on which a desirable structure and/or function can be constructed for biomedical and industrial application. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association